Sunday, February 21, 2010

Find a protein using PDB explorer-describe your protein, including what disease state or other real-world application it has.

The protein that I chose to look at was Lactose-Liganded Congerin I. This particular protein is part of the galectin family and is found in the skin mucous of the conger eel. Proteins from the galectin family perform several different biological activities. Congerin I is known for its activity against marine bacteria and starfish embryos. As such it is also plays an important role in conger eels’ biological defense mechanism against parasites. The structure of Congerin I is shown to the left. As is evident the protein is a homodimer and as such it possesses secondary structure. Lastly this secondary structure has a bounty of both alpha helices and beta pleated sheets.

2 comments:

  1. Genetics research is very actively involved in collecting different genetic materials from a wide assortment of animals. A new discovery in Australia found that the genetic sequence of the kangaroo is closer to humans than first believed. They are studying how the kangaroo can arrest development of their embryos until favorable environmental factors return. Researchers are studying this phenomenon for possible application is arresting cancer cells growth and replication. (Discovery Channel) Jane Russell

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  2. Were you able to find information on if a starfish can actually lay their eggs in the eel's ear since this is where this protein is found? Sounds creepy....

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